Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

被引：258

作者：

Herman, Mark A.

Kahn, Barbara B.

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Dept Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 07期

关键词：

D O I：

10.1172/JCI29027

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.

引用

收藏

页码：1767 / 1775

页数：9

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