Protease degradomics:: A new challenge for proteomics

被引：569

作者：

López-Otin, C

Overall, CM ^{[1
]}

机构：

[1] Univ British Columbia, Dept Biochem & Mol Biol, Prot Engn Network, Ctr Excellence, Vancouver, BC V6T 1Z3, Canada

[2] Univ British Columbia, Dept Oral Biol, Prot Engn Network, Ctr Excellence, Vancouver, BC V6T 1Z3, Canada

[3] Univ British Columbia, Dept Med Sci, Prot Engn Network, Ctr Excellence, Vancouver, BC V6T 1Z3, Canada

[4] Univ Oviedo, Dept Bioquim & Biol Mol, Fac Med, Inst Oncol, Oviedo 33006, Spain

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 07期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nrm858

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Degradomics - the application of genomic and proteomic approaches to identify the protease and protease-substrate repertoires, or 'degradomes', on an organism-wide scale - promises to uncover new roles for proteases in vivo. This knowledge will facilitate the identification of new pharmaceutical targets to treat disease. Here, we review emerging degradomic techniques and concepts.

引用

页码：509 / 519

页数：11

共 49 条

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