Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

被引：361

作者：

Pantaleo, G ^{[1
]}

Koup, RA

机构：

[1] Univ Lausanne, CHU Vaudois, Dept Med, Div Immunol & Allergy,Lab AIDS Immunopathogenesis, CH-1011 Lausanne, Switzerland

[2] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 08期

关键词：

D O I：

10.1038/nm0804-806

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of vaccinology began in ignorance of how protection was instilled in vaccine recipients. Today, a greater knowledge of immunology allows us to better understand what is being stimulated by various vaccines that leads to their protective effects: that is, their correlates of protection. Here we describe what is known about the correlates of protection for existing vaccines against a range of different viral diseases and discuss the correlates of protection against disease during natural infection with HIV-1. We will also discuss why it is important to design phase 3 clinical trials of HIV vaccines to determine the correlates of protection for each individual vaccine.

引用

页码：806 / 810

页数：5

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