NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings

被引：88

作者：

An, Omer ^{[1
]}

Dall'Olio, Giovanni M. ^{[1
]}

Mourikis, Thanos P. ^{[1
]}

Ciccarelli, Francesca D. ^{[1
]}

机构：

[1] Kings Coll London, Div Canc Studies, London SE1 1UL, England

来源：

NUCLEIC ACIDS RESEARCH | 2016年 / 44卷 / D1期

关键词：

TERT PROMOTER MUTATIONS; NETWORK PROPERTIES; IDENTIFICATION; RESOURCE; PROTEIN; INTEGRATION; DATABASE; DUPLICABILITY; HETEROGENEITY; TRANSCRIPTOME;

D O I：

10.1093/nar/gkv1123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Network of Cancer Genes (NCG, http://ncg.kcl.ac.uk/) is a manually curated repository of cancer genes derived from the scientific literature. Due to the increasing amount of cancer genomic data, we have introduced a more robust procedure to extract cancer genes frompublished cancer mutational screenings and two curators independently reviewed each publication. NCG release 5.0 (August 2015) collects 1571 cancer genes from 175 published studies that describe 188 mutational screenings of 13 315 cancer samples from 49 cancer types and 24 primary sites. In addition to collecting cancer genes, NCG also provides information on the experimental validation that supports the role of these genes in cancer and annotates their properties (duplicability, evolutionary origin, expression profile, function and interactions with proteins and miRNAs).

引用

页码：D992 / D999

页数：8

共 59 条

[1]

NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes [J].

An, Omer ;

Pendino, Vera ;

D'Antonio, Matteo ;

Ratti, Emanuele ;

Gentilini, Marco ;

Ciccarelli, Francesca D. .

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2014,

[2]

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity [J].

Barretina, Jordi ;

Caponigro, Giordano ;

Stransky, Nicolas ;

Venkatesan, Kavitha ;

Margolin, Adam A. ;

Kim, Sungjoon ;

Wilson, Christopher J. ;

Lehar, Joseph ;

Kryukov, Gregory V. ;

Sonkin, Dmitriy ;

Reddy, Anupama ;

Liu, Manway ;

Murray, Lauren ;

Berger, Michael F. ;

Monahan, John E. ;

Morais, Paula ;

Meltzer, Jodi ;

Korejwa, Adam ;

Jane-Valbuena, Judit ;

Mapa, Felipa A. ;

Thibault, Joseph ;

Bric-Furlong, Eva ;

Raman, Pichai ;

Shipway, Aaron ;

Engels, Ingo H. ;

Cheng, Jill ;

Yu, Guoying K. ;

Yu, Jianjun ;

Aspesi, Peter, Jr. ;

de Silva, Melanie ;

Jagtap, Kalpana ;

Jones, Michael D. ;

Wang, Li ;

Hatton, Charles ;

Palescandolo, Emanuele ;

Gupta, Supriya ;

Mahan, Scott ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Liefeld, Ted ;

MacConaill, Laura ;

Winckler, Wendy ;

Reich, Michael ;

Li, Nanxin ;

Mesirov, Jill P. ;

Gabriel, Stacey B. ;

Getz, Gad ;

Ardlie, Kristin ;

Chan, Vivien ;

Myer, Vic E. .

NATURE, 2012, 483 (7391) :603-607

[3]

The ChEMBL bioactivity database: an update [J].

Bento, A. Patricia ;

Gaulton, Anna ;

Hersey, Anne ;

Bellis, Louisa J. ;

Chambers, Jon ;

Davies, Mark ;

Krueger, Felix A. ;

Light, Yvonne ;

Mak, Lora ;

McGlinchey, Shaun ;

Nowotka, Michal ;

Papadatos, George ;

Santos, Rita ;

Overington, John P. .

NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) :D1083-D1090

[4]

TERT promoter mutations and telomerase reactivation in urothelial cancer [J].

Borah, Sumit ;

Xi, Linghe ;

Zaug, Arthur J. ;

Powell, Natasha M. ;

Dancik, Garrett M. ;

Cohen, Scott B. ;

Costello, James C. ;

Theodorescu, Dan ;

Cech, Thomas R. .

SCIENCE, 2015, 347 (6225) :1006-1010

[5]

The BioGRID interaction database: 2015 update [J].

Chatr-aryamontri, Andrew ;

Breitkreutz, Bobby-Joe ;

Oughtred, Rose ;

Boucher, Lorrie ;

Heinicke, Sven ;

Chen, Daici ;

Stark, Chris ;

Breitkreutz, Ashton ;

Kolas, Nadine ;

O'Donnell, Lara ;

Reguly, Teresa ;

Nixon, Julie ;

Ramage, Lindsay ;

Winter, Andrew ;

Sellam, Adnane ;

Chang, Christie ;

Hirschman, Jodi ;

Theesfeld, Chandra ;

Rust, Jennifer ;

Livstone, Michael S. ;

Dolinski, Kara ;

Tyers, Mike .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D470-D478

[6]

Studying Tumorigenesis through Network Evolution and Somatic Mutational Perturbations in the Cancer Interactome [J].

Cheng, Feixiong ;

Jia, Peilin ;

Wang, Quan ;

Lin, Chen-Ching ;

Li, Wen-Hsiung ;

Zhao, Zhongming .

MOLECULAR BIOLOGY AND EVOLUTION, 2014, 31 (08) :2156-2169

[7]

A New Initiative on Precision Medicine [J].

Collins, Francis S. ;

Varmus, Harold .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) :793-795

[8]

Recessive Cancer Genes Engage in Negative Genetic Interactions with Their Functional Paralogs [J].

D'Antonio, Matteo ;

Guerra, Rosalinda F. ;

Cereda, Matteo ;

Marchesi, Stefano ;

Montani, Francesca ;

Nicassio, Francesco ;

Di Fiore, Pier Paolo ;

Ciccarelli, Francesca D. .

CELL REPORTS, 2013, 5 (06) :1519-1526

[9]

Integrated analysis of recurrent properties of cancer genes to identify novel drivers [J].

D'Antonio, Matteo ;

Ciccarelli, Francesca D. .

GENOME BIOLOGY, 2013, 14 (05)

[10]

Modification of Gene Duplicability during the Evolution of Protein Interaction Network [J].

D'Antonio, Matteo ;

Ciccarelli, Francesca D. .

PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (04)

← 1 2 3 4 5 6 →