Diterpenes from the leaves of Croton zambesicus

被引：88

作者：

Block, S

Baccelli, C

Tinant, B

Van Meervelt, L

Rozenberg, R

Jiwan, JLH

Llabrès, G

De Pauw-Gillet, MC

Quetin-Leclercq, J

机构：

[1] Catholic Univ Louvain, Lab Pharmacognosie, Unite CHAM, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Dept Chim, Unite CSTR, B-1348 Louvain, Belgium

[3] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium

[4] Catholic Univ Louvain, Lab Spectrometrie Masse, B-1348 Louvain, Belgium

[5] Univ Liege, Dept Phys Expt, B-4000 Liege, Belgium

[6] Univ Liege, CRCE, B-4020 Liege, Belgium

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 08期

关键词：

Croton zambesicus; Euphorbiaceae; diterpene; trachylobane; pimarane; cytotoxicity;

D O I：

10.1016/j.phytochem.2004.02.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one-, isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1165 / 1171

页数：7

共 33 条

[1]

ADJANOHOUN EJ, 1989, CONTRIBUTION ETUDES, V1, P245

[2]

AIYAR VN, 1969, INDIAN J CHEM, V7, P838

[3]

AIYAR VN, 1971, INDIAN J CHEM, V9, P1055

[4] Chemical constituents of Indian mangrove plants -: Part-VIII -: Agallochins J-L, new isopimarane diterpenoids from Excoecaria agallocha L. [J].