Male specific expression suggests role of DMRT1 in human sex determination

被引：111

作者：

Moniot, B

Berta, P

Scherer, G

Südbeck, P

Poulat, F

机构：

[1] Univ Freiburg, Inst Humangenet & Anthropol, D-79106 Freiburg, Germany

[2] Inst Genet Humaine, CNRS, UPR 1142, F-34396 Montpellier 5, France

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 91卷 / 1-2期

关键词：

DMRT1; SRY; male sex determination; Sertoli cells; genital ridge; human embryo;

D O I：

10.1016/S0925-4773(99)00267-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sex determination in mammals is controlled by various transcription factors. Following the identification of SRY on the Y chromosome, several other factors have been identified. They can normally be identified as being involved in sex determination by the identification of sex reversal mutations or deletions, functional studies, and also by male-specific expression patterns in embryos. Here, it is shown that DMRT1, recently demonstrated to be deleted in 9p monosomies associated with sex reversal, is specifically expressed during sex determination in the genital ridge of human male, but not female, embryos, similar to SRY. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：323 / 325

页数：3

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