Plasma changes of calcitonin gene-related peptide and substance P in patients with dialysis headache

被引：28

作者：

Alessandri, M. ^{[1
]}

Massanti, L.

Geppetti, P.

Bellucci, G.

Cipriani, M.

Fanciullacci, M.

机构：

[1] Misericordia Hosp, Dept Internal Med, Headache Ctr, Grosseto, Italy

[2] Misericordia Hosp, Nephrol & Dialysis Unit, Dept Med Special, Grosseto, Italy

[3] Univ Florence, Clin Pharmacol Unit, Dept Crit Care Med & Surg, Florence, Italy

[4] Univ Florida, Dept Internal Med, Headache Ctr, Florence, Italy

来源：

CEPHALALGIA | 2006年 / 26卷 / 11期

关键词：

calcitonin gene-related peptide; dialysis headache; substance P; trigeminovascular system;

D O I：

10.1111/j.1468-2982.2006.01217.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Little is known of mechanism of dialysis headache (DH). As suggested for migraine, a role for neuropeptides has been investigated. Twenty-four patients under haemodialysis were studied. Twelve of them suffered from DH. The remaining patients were headache free. Blood samples for radioimmunoassay of calcitonin gene-related peptide (CGRP) and substance P (SP) were collected from the arteriovenous fistula before and after dialysis treatment. Basal plasma concentrations of CGRP were found to be higher in headache patients. Dialysis significantly decreased CGRP concentrations in both groups. No difference in basal plasma concentrations of SP was observed between groups. At the end of the treatment plasma SP concentrations were reduced in headache-free patients but increased in headache patients. Elevated plasma concentrations of CGRP in patients with DH could represent a biochemical factor contributing to susceptibility to headache. Because of the disputable role of SP in migraine, the significance of the increase of the peptide in plasma during DH remains to be elucidated.

引用

页码：1287 / 1293

页数：7

共 46 条

[21] CHANGES IN PLASMA-LEVELS OF VASOACTIVE PEPTIDES DURING STANDARD BICARBONATE HEMODIALYSIS [J].

HEGBRANT, J ;

THYSELL, H ;

MARTENSSON, L ;

EKMAN, R ;

BOBERG, U .

NEPHRON, 1993, 63 (03) :303-308

[22] Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase [J].

JansenOlesen, I ;

Mortensen, A ;

Edvinsson, L .

CEPHALALGIA, 1996, 16 (05) :310-316

[23] STUDIES ON BRAIN DENSITY IN HEMODIALYSIS AND PERITONEAL-DIALYSIS [J].

LAGRECA, G ;

BIASIOLI, S ;

CHIARAMONTE, S ;

DETTORI, P ;

FABRIS, A ;

FERIANI, M ;

PINNA, V ;

PISANI, E ;

RONCO, C .

NEPHRON, 1982, 31 (02) :146-150

[24] CGRP may play a causative role in migraine [J].

Lassen, LH ;

Haderslev, P ;

Jacobsen, VB ;

Iversen, HK ;

Sperling, B ;

Olesen, J .

CEPHALALGIA, 2002, 22 (01) :54-61

[25] Improvement of dialysis headache after treatment with ACE-inhibitors but not angiotensin II receptor blocker:: a case report with pathophysiological considerations [J].

Leinisch-Dahlke, E ;

Schmidt-Wilcke, T ;

Krämer, BK ;

May, A .

CEPHALALGIA, 2005, 25 (01) :71-74

[26] Salivary substance P, 5-hydroxytryptamine, and gamma-aminobutyric acid levels in migraine and tension-type headache [J].

Marukawa, H ;

Shimomura, T ;

Takahashi, K .

HEADACHE, 1996, 36 (02) :100-104

[27] TRIGEMINAL PROJECTIONS TO SUPRATENTORIAL PIAL AND DURAL BLOOD-VESSELS IN CATS DEMONSTRATED BY HORSERADISH-PEROXIDASE HISTOCHEMISTRY [J].

MAYBERG, MR ;

ZERVAS, NT ;

MOSKOWITZ, MA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1984, 223 (01) :46-56

[28] Study of pressure pain and cellular concentration of neurotransmitters related to nociception in episodic tension-type headache patients [J].

Mazzotta, G ;

Sarchielli, P ;

Gaggioli, A ;

Gallai, V .

HEADACHE, 1997, 37 (09) :565-571

[29]

MOSKOWITZ MA, 1993, NEUROLOGY, V43, P16

[30]

MOSKOWITZ MA, 1993, CEREBROVAS BRAIN MET, V5, P159

← 1 2 3 4 5 →