Chronic myeloid leukemia with a rare variant Philadelphia translocation: t(9;22;21)(q34;q11;q22)

被引：6

作者：

Guillaume, B

Ameye, G

Libouton, JM

Dierlamm, J

Vaerman, JL

Straetmans, N

Ferrant, A

Verellen-Dumoulin, C

Michaux, L

机构：

[1] Univ Catholique Louvain, Ctr Med Genet, Brussels, Belgium

[2] Clin Univ St Luc, Dept Hematol, B-1200 Brussels, Belgium

[3] Univ Hosp Eppendorf, Dept Hematol & Oncol, Hamburg, Germany

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 116卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(99)00115-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed. (C) Elsevier Science Inc., 1999. All rights reserved.

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页码：166 / 169

页数：4

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