Fast and efficient synthesis of novel fumagillin analogues

被引：27

作者：

Baldwin, JE ^{[1
]}

Bulger, PG ^{[1
]}

Marquez, R ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON | 2002年 / 58卷 / 27期

关键词：

fumagillin; TNP-470; angiogenesis inhibitors; analogues; furan rearrangement;

D O I：

10.1016/S0040-4020(02)00514-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel class of non-carbocyclic ring analogues of the potent angiogenesis inhibitors fumagillin and TNP-470 have been enantioselectively and efficiently synthesised starting from pyridine-2-thiol in 10 steps in excellent overall yield. (C) 2002 Elsevier Science. Ltd. All rights reserved.

引用

页码：5441 / 5452

页数：12

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