Selection and analytical applications of aptamers

被引：242

作者：

Hamula, Camille L. A.

Guthrie, Jeffrey W.

Zhang, Hongquan

Li, Xing-Fang

Le, X. Chris ^{[1
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada

[2] Univ Alberta, Fac Med & Dent, Dept Lab Med & Pathol, Edmonton, AB T6G 2G3, Canada

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2006年 / 25卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

affinity binding; aptamer; bioanalytical assay; biosensor; chiral separation; in vitro selection; protein; SELEX;

D O I：

10.1016/j.trac.2006.05.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Advances in systematic evolution of ligands by exponential enrichment (SELEX), a selection protocol for aptamers, have resulted in increased applications of DNA and RNA aptamers in developing analytical techniques. We review recent developments in SELEX techniques as well as new aptamer-based bioanalytical applications. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：681 / 691

页数：11

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