Perspectives on next steps in classification of oro-facial pain - Part 3: biomarkers of chronic oro-facial pain - from research to clinic

被引：10

作者：

Ceusters, W. ^{[1
]}

Nasri-Heir, C. ^{[2
]}

Alnaas, D. ^{[2
]}

Cairns, B. E. ^{[3
]}

Michelotti, A. ^{[4
]}

Ohrbach, R. ^{[5
]}

机构：

[1] SUNY Buffalo, Dept Biomed Informat, Buffalo, NY 14214 USA

[2] Rutgers Sch Dent Med, Newark, NJ USA

[3] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada

[4] Univ Naples Federico II, Sch Dent, Sect Orthodont, Naples, Italy

[5] SUNY Buffalo, Dept Oral Diagnost Sci, Buffalo, NY 14214 USA

来源：

JOURNAL OF ORAL REHABILITATION | 2015年 / 42卷 / 12期

关键词：

chronic oro-facial pain; temporomandib ular disorders; pain; biomarkers; ontology; classification; NOXIOUS INHIBITORY CONTROLS; JAW-STRETCH REFLEXES; TEMPOROMANDIBULAR-JOINT PAIN; INFLAMMATORY NEURITIS SIN; RAT INFRAORBITAL NERVE; MUSCLE PAIN; TEMPORAL SUMMATION; MASSETER MUSCLE; 2ND PAIN; WIDESPREAD PAIN;

D O I：

10.1111/joor.12324

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

The purpose of this study was to review the current status of biomarkers used in oro-facial pain conditions. Specifically, we critically appraise their relative strengths and weaknesses for assessing mechanisms associated with the oro-facial pain conditions and interpret that information in the light of their current value for use in diagnosis. In the third section, we explore biomarkers through the perspective of ontological realism. We discuss ontological problems of biomarkers as currently widely conceptualised and implemented. This leads to recommendations for research practice aimed to a better understanding of the potential contribution that biomarkers might make to oro-facial pain diagnosis and thereby fulfil our goal for an expanded multidimensional framework for oro-facial pain conditions that would include a third axis.

引用

页码：956 / 966

页数：11

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