Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

被引：122

作者：

Skibola, Christine F. ^{[1
]}

Bracci, Paige M. ^{[2
]}

Halperin, Eran ^{[3
]}

Conde, Lucia ^{[1
]}

Craig, David W. ^{[4
]}

Agana, Luz ^{[1
]}

Iyadurai, Kelly ^{[4
]}

Becker, Nikolaus ^{[5
]}

Brooks-Wilson, Angela ^{[6
]}

Curry, John D. ^{[1
]}

Spinelli, John J. ^{[7
]}

Holly, Elizabeth A. ^{[2
]}

Riby, Jacques ^{[1
]}

Zhang, Luoping ^{[1
]}

Nieters, Alexandra ^{[5
,8
]}

Smith, Martyn T. ^{[1
]}

Brown, Kevin M. ^{[4
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[3] Int Comp Sci Inst, Berkeley, CA 94704 USA

[4] Translat Genom Res Inst, Phoenix, AZ USA

[5] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[6] Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada

[7] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada

[8] Univ Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany

来源：

NATURE GENETICS | 2009年 / 41卷 / 08期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

NON-HODGKIN-LYMPHOMA; GENOME-WIDE ASSOCIATION; POLYMORPHISMS;

D O I：

10.1038/ng.419

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

引用

页码：873 / 875

页数：3

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