Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73

被引：59

作者：

Dietz, S

Rother, K

Bamberger, C

Schmale, H

Mössner, J

Engeland, K

机构：

[1] Univ Leipzig, Max Burger Forschungszentrum, Med Klin & Poliklin 2, D-04103 Leipzig, Germany

[2] Univ Hamburg, Inst Zellbiol & Klin Neurobiol, D-20246 Hamburg, Germany

来源：

FEBS LETTERS | 2002年 / 525卷 / 1-3期

关键词：

p53; p63; p73; transcription; apoptosis;

D O I：

10.1016/S0014-5793(02)03093-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p53 tumor suppressor acts as a transcription factor and has a central function in controlling apoptosis. With p63 and p73 two genes coding for proteins homologous to p53 have been identified. We describe the properties of seven human p63 and p73 proteins as transcriptional activators of p21WAF1/CIP1 expression and apoptotic inducers in direct comparison to p53 in the same assay systems employing DLD-1-tet-off colon cells. Programmed cell death is detected in cells expressing high levels of p53 and p73alpha. Cells overexpressing TAp63alpha, TAp63gamma, TA*p63alpha, TA*p63gamma, DeltaNp63alpha, and DeltaNp63gamma display low or no detectable apoptosis. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：93 / 99

页数：7

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