cAMP and Ca2+ signaling in secretory epithelia: Crosstalk and synergism

被引：84

作者：

Ahuja, Malini ^{[1
]}

Jha, Archana ^{[1
]}

Maleth, Jozsef ^{[1
]}

Park, Seonghee ^{[2
]}

Muallem, Shmuel ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Epithelial Signaling & Transport Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA

[2] Ewha Womans Univ, Sch Med, Dept Physiol, Seoul 158710, South Korea

来源：

CELL CALCIUM | 2014年 / 55卷 / 06期

关键词：

IRBIT; Synergism; Duct epithelia; Calcium signaling; PROTEIN-KINASE-A; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; PLASMA-MEMBRANE CA2+-ATPASE; ADENYLYL-CYCLASE; HCO3-SECRETION; GUINEA-PIG; MEDIATED PHOSPHORYLATION; MOLECULAR-MECHANISM; SUBMUCOSAL GLANDS;

D O I：

10.1016/j.ceca.2014.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The Ca2+ and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca2+ and CAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca2+ and cAMP signaling operate at 5-10% of maximal strength, but synergize to generate the maximal response. Although synergistic action of the Ca2+ and cAMP signaling is the common mode of signaling and has been known for many years, we know very little of the molecular mechanism and mediators of the synergism. In this review, we discuss crosstalk between the Ca2+ and cAMP signaling and the function of IRBIT (IP3 receptors binding protein release with IP3) as a third messenger that mediates the synergistic action of the Ca2+ and cAMP signaling. (C) 2014 Published by Elsevier Ltd.

引用

页码：385 / 393

页数：9

共 126 条

[1]

Vasoactive intestinal peptide potentiates and directly stimulates catecholamine secretion from rat adrenal chromaffin cells [J].