Covalent attachment of low molecular weight poly(ethylene imine) improves tat peptide mediated gene delivery

被引：53

作者：

Alexis, Frank

Lo, Seong-Loong

Wang, Shu

机构：

[1] Inst Bioengn & Nanotechnol, Gene Delivery Grp, Singapore 138669, Singapore

[2] Natl Univ Singapore, Gene Delivery Grp, Inst Bioengn & Nanotechnol, Dept Sci Biol, Singapore 117543, Singapore

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 16期

关键词：

POLYETHYLENIMINE; VECTOR; TRANSFECTION; CYTOTOXICITY; DERIVATIVES;

D O I：

10.1002/adma.200502173

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A polymer-peptide hybrid biomaterial synthesized by coupling poly(ethylene imine) directly to resin-supported Tat peptide takes advantage of the unique features associated with the two original cationic materials and functions as a novel gene-delivery vector with good biocompatibility. The figure shows cells transfected with green fluorescent protein (GFP) using complexes of the polymer-peptide hybrid and GFP (scale bar: 100 mu m).

引用

收藏

页码：2174 / +

页数：6

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