PACAP immunoreactivity in the rat superior cervical ganglion in comparison to VIP

被引:34
作者
Klimaschewski, L [1 ]
Hauser, C [1 ]
Heym, C [1 ]
机构
[1] GEN HOSP ST JOHNS,DEPT PATHOL ANAT,SALZBURG,AUSTRIA
关键词
axotomy; decentralization; pituitary adenylate cyclase activating peptide; sympathetic; vasoactive intestinal peptide;
D O I
10.1097/00001756-199611040-00078
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE presence and regulation of pituitary adenylate cyclase activating peptide (PACAP) was investigated in the adult rat superior cervical ganglion. Double-labelling immunofluorescence using specific antibodies against PACAP and vasoactive intestinal peptide (VIP) revealed a dense innervation of postganglionic sympathetic neurones by PACAP-immunoreactive but VIP-negative nerve endings that mainly were of preganglionic origin since they disappeared after transection of the cervical sympathetic trunk. Since PACAP regulates transmitter synthesis and release in sympathetic neurones in vitro, this finding provides a morphological correlate for modulatory effects of PACAP in vivo. Few neurones contained PACAP under normal conditions. However, the number of PACAP-positive neurones increased in response to axotomy of the postganglionic nerves. Many of the newly PACAP-positive neurones also contained VIP, suggesting that both peptides are regulated by similar mechanisms.
引用
收藏
页码:2797 / 2801
页数:5
相关论文
共 18 条
[1]   RECEPTORS FOR PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE - COMPARISON WITH VASOACTIVE-INTESTINAL-PEPTIDE RECEPTORS [J].
ARIMURA, A .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1992, 3 (08) :288-294
[2]   PROPERTIES AND DISTRIBUTION OF RECEPTORS FOR PITUITARY ADENYLATE-CYCLASE ACTIVATING PEPTIDE (PACAP) IN RAT-BRAIN AND SPINAL-CORD [J].
CAUVIN, A ;
ROBBERECHT, P ;
DENEEF, P ;
GOURLET, P ;
VANDERMEERS, A ;
VANDERMEERSPIRET, MC ;
CHRISTOPHE, J .
REGULATORY PEPTIDES, 1991, 35 (02) :161-173
[3]   PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) POTENTLY STIMULATES MITOSIS, NEURITOGENESIS AND SURVIVAL IN CULTURED RAT SYMPATHETIC NEUROBLASTS [J].
DICICCOBLOOM, E ;
DEUTSCH, PJ .
REGULATORY PEPTIDES, 1992, 37 (03) :319-319
[4]   REGULATION OF INTERLEUKIN-6 (IL-6) SECRETION IN PRIMARY CULTURED RAT ASTROCYTES - SYNERGISM OF INTERLEUKIN-1 (IL-1) AND PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) [J].
GOTTSCHALL, PE ;
TATSUNO, I ;
ARIMURA, A .
BRAIN RESEARCH, 1994, 637 (1-2) :197-203
[5]   PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE STIMULATES NEURITE GROWTH IN PC12 CELLS [J].
HERNANDEZ, A ;
KIMBALL, B ;
ROMANCHUK, G ;
MULHOLLAND, MW .
PEPTIDES, 1995, 16 (05) :927-932
[6]  
HYATTSACHS H, 1993, J NEUROSCI, V13, P1642
[7]   VASOACTIVE-INTESTINAL-PEPTIDE BUT NOT GALANIN PROMOTES SURVIVAL OF NEONATAL RAT SYMPATHETIC NEURONS AND NEURITE OUTGROWTH OF PC12 CELLS [J].
KLIMASCHEWSKI, L ;
UNSICKER, K ;
HEYM, C .
NEUROSCIENCE LETTERS, 1995, 195 (02) :133-136
[8]   PLASTICITY OF POSTGANGLIONIC SYMPATHETIC NEURONS IN THE RAT SUPERIOR CERVICAL-GANGLION AFTER AXOTOMY [J].
KLIMASCHEWSKI, L ;
TRAN, TD ;
NOBILING, R ;
HEYM, C .
MICROSCOPY RESEARCH AND TECHNIQUE, 1994, 29 (02) :120-130
[9]  
MANTYH PW, 1992, NEUROSCIENCE, V46, P739, DOI 10.1016/0306-4522(92)90160-4
[10]   REGIONAL DISTRIBUTION OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) IN THE RAT CENTRAL-NERVOUS-SYSTEM AS DETERMINED BY SANDWICH-ENZYME IMMUNOASSAY [J].
MASUO, Y ;
SUZUKI, N ;
MATSUMOTO, H ;
TOKITO, F ;
MATSUMOTO, Y ;
TSUDA, M ;
FUJINO, M .
BRAIN RESEARCH, 1993, 602 (01) :57-63