Execution of nonsense-mediated mRNA decay: what defines a substrate?

被引：214

作者：

Rebbapragada, Indrani ^{[1
]}

Lykke-Andersen, Jens ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 03期

基金：

美国国家科学基金会;

关键词：

EXON-JUNCTION COMPLEX; CAENORHABDITIS-ELEGANS; TRANSLATION INITIATION; TERMINATION-CODON; BINDING PROTEIN; SACCHAROMYCES-CEREVISIAE; POLY(A)-BINDING PROTEIN; SURVEILLANCE COMPLEX; MAMMALIAN-CELLS; UPF PROTEINS;

D O I：

10.1016/j.ceb.2009.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nonsense-mediated mRNA decay (NMD) pathway targets mRNAs with premature termination codons as well as a subset of normal mRNAs for rapid decay. Emerging evidence suggests that mRNAs become NMD substrates based on the composition of the mRNP downstream of the translation termination event, which either stimulates or antagonizes recruitment of the NMD machinery. The NMD mRNP subsequently undergoes several remodeling events, which involve hydrolysis of ATP by the NMD factor Upf1 and in metazoans, a phosphorylation/dephosphorylation cycle of Upf1 mediated by Smg proteins. This leads to mRNA decay following translational repression. Recent evidence suggests that in Drosophila and human cells, decay is initiated by the endonuclease Smg6.

引用

页码：394 / 402

页数：9

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