Synthesis and biochemical properties of E-ring modified luotonin A derivatives

被引：48

作者：

Cagir, A

Jones, SH

Eisenhauer, BM

Gao, R

Hecht, SM

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

[2] Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期

关键词：

topoisomerase I poisons; antineoplastic agents; cytotoxic alkaloids;

D O I：

10.1016/j.bmcl.2004.02.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion Lis the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2051 / 2054

页数：4

共 44 条

[1]

BJORNSTI MA, 1989, CANCER RES, V49, P6318

[2] Luotonin A. A naturally occurring human DNA topoisomerase I poison [J].