A convenient synthesis of luotonins A and B

被引：52

作者：

Harayama, T ^{[1
]}

Morikami, Y ^{[1
]}

Shigeta, Y ^{[1
]}

Abe, H ^{[1
]}

Takeuchi, Y ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

SYNLETT | 2003年 / 06期

关键词：

palladium; cytotoxic activity; pyrroloquinazoline alkaloid;

D O I：

10.1055/s-2003-38748

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of the cytotoxic alkaloid, luotonin A, was achieved using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc in high yield. Successive treatment of luotonin A with NBS and aq AgNO3 gave luotonin B in good yield.

引用

页码：847 / 848

页数：2

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