Danger, death and DNA vaccines

被引：20

作者：

Bergmann-Leitner, ES

Leitner, WW

机构：

[1] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA

[2] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 03期

关键词：

DNA vaccine; apoptosis; innate immunity;

D O I：

10.1016/j.micinf.2003.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA vaccines, although successful in many animal models of various diseases, remain insufficiently immunogenic in humans. Among the countless approaches to improve them is the stimulation of the innate immune system by promoting the apoptotic death of the transfected host cells, which is the focus of this review. (C) 2003 Elsevier SAS. All rights reserved.

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收藏

页码：319 / 327

页数：9

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