Cancer-related inflammation and treatment effectiveness

被引：1878

作者：

Diakos, Connie I. ^{[1
]}

Charles, Kellie A. ^{[2
]}

McMillan, Donald C. ^{[3
]}

Clarke, Stephen J. ^{[1
]}

机构：

[1] Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Sydney, NSW 2006, Australia

[2] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[3] Univ Glasgow, Royal Infirm, Sch Med, Acad Surg Unit, Glasgow, Lanark, Scotland

来源：

LANCET ONCOLOGY | 2014年 / 15卷 / 11期

关键词：

C-REACTIVE PROTEIN; NF-KAPPA-B; COLORECTAL-CANCER; SUPPRESSOR-CELLS; PROGNOSTIC VALUE; TUMOR NECROSIS; LYMPHOCYTE RATIO; MYELOID CELLS; THERAPY; SURVIVAL;

D O I：

10.1016/S1470-2045(14)70263-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammation is a recognised hallmark of cancer that substantially contributes to the development and progression of malignancies. In established cancers, there is increasing evidence for the roles that local immune response and systemic inflammation have in progression of tumours and survival of patients with cancer. This knowledge provides an opportunity to target these inflammatory responses to improve patient outcomes. In this Review, we examine the complex interplay between local immune responses and systemic inflammation, and their influence on clinical outcomes, and propose potential anti-inflammatory interventions for patients with cancer.

引用

页码：E493 / E503

页数：11

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