Emergence and pandemic potential of swine-origin H1N1 influenza virus

被引：1199

作者：

Neumann, Gabriele ^{[1
]}

Noda, Takeshi ^{[3
]}

Kawaoka, Yoshihiro ^{[1
,2
,3
,4
]}

机构：

[1] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA

[2] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo 1088639, Japan

[3] Univ Tokyo, Int Res Ctr Infect Dis, Tokyo 1088639, Japan

[4] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Kawaguchi, Saitama 3320012, Japan

来源：

NATURE | 2009年 / 459卷 / 7249期

基金：

日本科学技术振兴机构;

关键词：

LOWER RESPIRATORY-TRACT; A H5N1 VIRUS; MEDIATED ANTIVIRAL RESPONSES; POLYMERASE SUBUNIT PB2; SINGLE-AMINO-ACID; MOLECULAR-BASIS; HOST-RANGE; IMMUNOCOMPROMISED CHILD; RECEPTOR SPECIFICITY; BACTERIAL PNEUMONIA;

D O I：

10.1038/nature08157

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. A prime example is the recent emergence of swine-origin H1N1 viruses that have transmitted to and spread among humans, resulting in outbreaks internationally. Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide us with invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.

引用

页码：931 / 939

页数：9

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