Synthesis of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones.

被引：16

作者：

Palmer, CF

Webb, B

Broad, S

Casson, S

McCague, R

Willetts, AJ

Roberts, SM

机构：

[1] UNIV EXETER,DEPT SCI BIOL,EXETER EX4 4QD,DEVON,ENGLAND

[2] UNIV EXETER,DEPT CHEM,EXETER EX4 4QG,DEVON,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期

关键词：

CARBOCYCLIC NUCLEOSIDES; DERIVATIVES; RESOLUTION; ACID;

D O I：

10.1016/S0960-894X(97)00217-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxymercuration/demercuration of 2-benzyl-2-azabicyclo[2.2.1]hept-5-en-3-one (1) and biohydroxylation of the corresponding saturated lactam (-)-(8) are compared as methods for the preparation of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones. (C) 1997 Elsevier Science Ltd.

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页码：1299 / 1302

页数：4

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