A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

被引：34

作者：

Li, CS ^{[1
]}

Black, WC ^{[1
]}

Brideau, C ^{[1
]}

Chan, CC ^{[1
]}

Charleson, S ^{[1
]}

Cromlish, WA ^{[1
]}

Claveau, D ^{[1
]}

Gauthier, JY ^{[1
]}

Gordon, R ^{[1
]}

Greig, G ^{[1
]}

Grimm, E ^{[1
]}

Guay, J ^{[1
]}

Lau, CK ^{[1
]}

Riendeau, D ^{[1
]}

Thérien, M ^{[1
]}

Visco, DM ^{[1
]}

Wong, E ^{[1
]}

Xu, LJ ^{[1
]}

Prasit, P ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Pointe Claire, PQ H9R 4P8, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(99)00559-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methanesulfonylphenyl)-2(5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3181 / 3186

页数：6

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