Comparative mortality risks of antipsychotic medications in community-dwelling older adults

Background All antipsychotic medications carry warnings of increased mortality for older adults, but little is known about comparative mortality risks between individual agents. Aims To estimate the comparative mortality risks of commonly prescribed antipsychotic agents in older people living in the community. Method A retrospective, claims-based cohort study was conducted of people over 65 years old living in the community who had been newly prescribed risperidone, olanzapine, quetiapine, haloperidol, aripiprazole or ziprasidone (0=136393). Propensity score-adjusted Cox proportional hazards models assessed the 180-day mortality risk of each antipsychotic compared with risperidone. Results Rispendone, olanzapine and haloperidol showed a dose-response relation in mortality risk. After controlling for propensity score and dose, mortality risk was found to be increased for haloperidol (hazard ratio (HR)=1.18, 95% CI 1.06-1.33) and decreased for quetiapine (HR=0.81, 95% Cl 0.73-0.89) and olanzapine (HR=0.82, 95% Cl 0.74-0.90). Conclusions Significant variation in mortality risk across commonly prescribed antipsychotics suggests that antipsychotic selection and dosing may affect survival of older people living in the community.