Determinants of the outcomes of patients with cancer infected with SARS-CoV-2: results from the Gustave Roussy cohort

被引：92

作者：

Albiges, Laurence ^{[1
]}

Foulon, Stephanie ^{[2
]}

Bayle, Arnaud ^{[1
]}

Gachot, Bertrand ^{[3
]}

Pommeret, Fanny ^{[1
,3
]}

Willekens, Christophe ^{[4
]}

Stoclin, Annabelle ^{[3
]}

Merad, Mansouria ^{[3
]}

Griscelli, Frank ^{[5
]}

Lacroix, Ludovic ^{[5
]}

Netzer, Florence ^{[6
]}

Hueso, Thomas ^{[4
]}

Balleyguier, Corinne ^{[7
]}

Ammari, Samy ^{[7
]}

Colomba, Emeline ^{[1
]}

Baciarello, Giulia ^{[1
]}

Perret, Audrey ^{[1
]}

Hollebecque, Antoine ^{[1
,8
]}

Hadoux, Julien ^{[7
]}

Michot, Jean-Marie ^{[8
]}

Chaput, Nathalie ^{[4
]}

Saada, Veronique ^{[5
]}

Hauchecorne, Mathilde ^{[1
]}

Micol, Jean-Baptiste ^{[4
]}

Sun, Roger ^{[9
]}

Valteau-Couanet, Dominique ^{[10
]}

Andre, Fabrice ^{[1
]}

Scotte, Florian ^{[3
]}

Besse, Benjamin ^{[1
]}

Soria, Jean-Charles ^{[11
]}

Barlesi, Fabrice ^{[11
,12
]}

机构：

[1] Paris Saclay Univ, Canc Med Dept, Gustave Roussy, Paris, France

[2] Paris Saclay Univ, Biostat Dept, Gustave Roussy, Paris, France

[3] Paris Saclay Univ, Interdisciplinary Canc Course Dept, Gustave Roussy, Paris, France

[4] Paris Saclay Univ, Haematol Dept, Gustave Roussy, Paris, France

[5] Paris Saclay Univ, Biopathol Dept, Gustave Roussy, Paris, France

[6] Paris Saclay Univ, Pharm Dept, Gustave Roussy, Paris, France

[7] Paris Saclay Univ, Imaging Dept, Gustave Roussy, Paris, France

[8] Paris Saclay Univ, Early Drug Dev Dept, Gustave Roussy, Paris, France

[9] Paris Saclay Univ, Radiat Oncol Dept, Gustave Roussy, Paris, France

[10] Paris Saclay Univ, Paediat Oncol Dept, Gustave Roussy, Paris, France

[11] Paris Saclay Univ, Gustave Roussy, Paris, France

[12] Aix Marseille Univ, CNRS, INSERM, CRCM, Marseille, France

来源：

NATURE CANCER | 2020年 / 1卷 / 10期

关键词：

COVID-19;

D O I：

10.1038/s43018-020-00120-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Patients with cancer are presumed to be at increased risk of severe COVID-19 outcomes due to underlying malignancy and treatment-induced immunosuppression. Of the first 178 patients managed for COVID-19 at the Gustave Roussy Cancer Centre, 125 (70.2%) were hospitalized, 47 (26.4%) developed clinical worsening and 31 (17.4%) died. An age of over 70years, smoking status, metastatic disease, cytotoxic chemotherapy and an Eastern Cooperative Oncology Group score of >= 2 at the last visit were the strongest determinants of increased risk of death. In multivariable analysis, the Eastern Cooperative Oncology Group score remained the only predictor of death. In contrast, immunotherapy, hormone therapy and targeted therapy did not increase clinical worsening or death risk. Biomarker studies found that C-reactive protein and lactate dehydrogenase levels were significantly associated with an increased risk of clinical worsening, while C-reactive protein and D-dimer levels were associated with an increased risk of death. COVID-19 management impacted the oncological treatment strategy, inducing a median 20d delay in 41% of patients and adaptation of the therapeutic strategy in 30% of patients. Barlesi and colleagues describe the determinants of severe COVID-19 outcomes in patients with cancer managed at the Gustave Roussy Cancer Centre.

引用

页码：965 / +

页数：15

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