The Rodent Hippocampus Is Essential for Nonspatial Object Memory

被引:255
作者
Cohen, Sarah J. [1 ]
Munchow, Alcira H. [2 ]
Rios, Lisa M. [2 ,3 ]
Zhang, Gongliang [2 ,4 ]
Asgeirsdottir, Herborg N. [2 ,3 ]
Stackman, Robert W., Jr. [1 ,2 ,3 ]
机构
[1] Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USA
[2] Florida Atlantic Univ, Dept Psychol, Boca Raton, FL 33431 USA
[3] Florida Atlantic Univ, FAU Max Planck Florida Inst, Joint Grad Program Integrat Biol & Neurosci, Boca Raton, FL 33431 USA
[4] Anhui Med Univ, Dept Physiol, Hefei 230032, Anhui, Peoples R China
关键词
MEDIAL TEMPORAL-LOBE; IMPAIRED RECOGNITION MEMORY; TO-SAMPLE TASK; PERIRHINAL CORTEX; INACTIVATION REVEALS; NEUROTOXIC LESIONS; DORSAL HIPPOCAMPUS; NEURONAL-ACTIVITY; SPATIAL MEMORY; PLACE CELLS;
D O I
10.1016/j.cub.2013.07.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Elucidating the role of the rodent hippocampus in object recognition memory is critical for establishing the appropriateness of rodents as models of human memory and for their use in the development of memory disorder treatments. In mammals, spatial memory [1-6] and nonspatial memory [7, 8] depend upon the hippocampus and associated medial temporal lobe (MTL) structures. Although well established in humans [1, 9], the role of the rodent hippocampus in object memory remains highly debated due to conflicting findings across temporary and permanent hippocampal lesion studies [10-22] and evidence that the perirhinal cortex may support object memory [17, 23, 24]. In the current studies, we used intrahippocampal muscimol microinfusions to transiently inactivate the male C57BL/6J mouse hippocampus at distinct stages during the novel object recognition (NOR) task: during object memory encoding and consolidation, just consolidation, and/or retrieval. We also assessed the effect of temporary hippocampal inactivation when objects were presented in different contexts, thus eliminating the spatial or contextual components of the task. Lastly, we assessed extracellular dorsal hippocampal glutamate efflux and firing properties of hippocampal neurons while mice performed the NOR task. Our results reveal a clear and compelling role of the rodent hippocampus in nonspatial object memory.
引用
收藏
页码:1685 / 1690
页数:6
相关论文
共 52 条
[1]
The role of the hippocampus in object recognition in rats: Examination of the influence of task parameters and lesion size [J].
Ainge, JA ;
Heron-Maxwell, C ;
Theofilas, P ;
Wright, P ;
de Hoz, L ;
Wood, ER .
BEHAVIOURAL BRAIN RESEARCH, 2006, 167 (01) :183-195
[2]
When Is the Hippocampus Involved in Recognition Memory? [J].
Barker, Gareth R. I. ;
Warburton, Elizabeth C. .
JOURNAL OF NEUROSCIENCE, 2011, 31 (29) :10721-10731
[3]
Grid cells require excitatory drive from the hippocampus [J].
Bonnevie, Tora ;
Dunn, Benjamin ;
Fyhn, Marianne ;
Hafting, Torkel ;
Derdikman, Dori ;
Kubie, John L. ;
Roudi, Yasser ;
Moser, Edvard I. ;
Moser, May-Britt .
NATURE NEUROSCIENCE, 2013, 16 (03) :309-317
[4]
Object recognition memory and the rodent hippocampus [J].
Broadbent, Nicola J. ;
Gaskin, Stephane ;
Squire, Larry R. ;
Clark, Robert E. .
LEARNING & MEMORY, 2010, 17 (01) :794-800
[5]
Spatial memory, recognition memory, and the hippocampus [J].
Broadbent, NJ ;
Squire, LR ;
Clark, RE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (40) :14515-14520
[6]
Recognition memory: What are the roles of the perirhinal cortex and hippocampus? [J].
Brown, MW ;
Aggleton, JP .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (01) :51-61
[7]
Burwell RD, 2000, ANN NY ACAD SCI, V911, P25
[8]
Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat [J].
Bussey, TJ ;
Duck, J ;
Muir, JL ;
Aggleton, JP .
BEHAVIOURAL BRAIN RESEARCH, 2000, 111 (1-2) :187-202
[9]
Clark RE, 2000, J NEUROSCI, V20, P8853
[10]
Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task [J].
Clark, RE ;
West, AN ;
Zola, SM ;
Squire, LR .
HIPPOCAMPUS, 2001, 11 (02) :176-186