Grid cells require excitatory drive from the hippocampus

被引：247

作者：

Bonnevie, Tora ^{[1
,2
]}

Dunn, Benjamin ^{[1
,2
]}

Fyhn, Marianne ^{[1
,2
]}

Hafting, Torkel ^{[1
,2
]}

Derdikman, Dori ^{[1
,2
]}

Kubie, John L. ^{[3
]}

Roudi, Yasser ^{[1
,2
]}

Moser, Edvard I. ^{[1
,2
]}

Moser, May-Britt ^{[1
,2
]}

机构：

[1] Norwegian Univ Sci & Technol NTNU, Kavli Inst Syst Neurosci, Trondheim, Norway

[2] Norwegian Univ Sci & Technol NTNU, Ctr Biol Memory, Norwegian Brain Ctr, Trondheim, Norway

[3] Suny Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 03期

基金：

欧洲研究理事会;

关键词：

MEDIAL ENTORHINAL CORTEX; SPATIAL REPRESENTATION SYSTEM; PLACE CELLS; THETA OSCILLATIONS; PHASE PRECESSION; PATH-INTEGRATION; COGNITIVE MAP; RAT; NEURONS; FIELDS;

D O I：

10.1038/nn.3311

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine how hippocampal backprojections influence spatially periodic firing in grid cells, we recorded neural activity in the medial entorhinal cortex (MEC) of rats after temporary inactivation of the hippocampus. We report two major changes in entorhinal grid cells. First, hippocampal inactivation gradually and selectively extinguished the grid pattern. Second, the same grid cells that lost their grid fields acquired substantial tuning to the direction of the rat's head. This transition in firing properties was contingent on a drop in the average firing rate of the grid cells and could be replicated by the removal of an external excitatory drive in an attractor network model in which grid structure emerges by velocity-dependent translation of activity across a network with inhibitory connections. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC.

引用

页码：309 / 317

页数：9

共 42 条

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