Pancreatic cancer genomics

被引：45

作者：

Chang, David K. ^{[1
,2
,3
,4
,5
,6
]}

Grimmond, Sean M. ^{[1
,7
]}

Biankin, Andrew V. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Glasgow, Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow G61 1BD, Lanark, Scotland

[2] Glasgow Royal Infirm, West Scotland Pancreat Unit, Glasgow G4 0SF, Lanark, Scotland

[3] Garvan Inst Med Res, Kinghorn Canc Ctr, Canc Div, Sydney, NSW 2010, Australia

[4] Univ NSW, St Vincents Clin Sch, Fac Med, Sydney, NSW, Australia

[5] Bankstown Hosp, Dept Surg, Sydney, NSW 2200, Australia

[6] Univ NSW, South Western Sydney Clin Sch, Fac Med, Liverpool, NSW 2170, Australia

[7] Univ Queensland, Inst Mol Biosci, Queensland Ctr Med Genom, St Lucia, Qld, Australia

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 24卷

关键词：

EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1; PHASE-II TRIAL; MUTATIONAL PROCESSES; FANCONI-ANEMIA; GEMCITABINE; SURVIVAL; THERAPY; ADENOCARCINOMA; DEPENDENCIES; TRASTUZUMAB;

D O I：

10.1016/j.gde.2013.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Pancreatic cancer is one of the most lethal malignancies. The overall median survival even with treatment is only 6-9 months, with almost 90% succumbing to the disease within a year of diagnosis. It is characterised by an intense desmoplastic stroma that may contribute to therapeutic resistance, and poses significant challenges for genomic sequencing studies. It is recalcitrant to almost all therapies and consequently remains the fourth leading cause of cancer death in Western societies. Genomic studies are unveiling a vast heterogeneity of mutated genes, and this diversity may explain why conventional clinical trial designs have mostly failed to demonstrate efficacy in unselected patients. Those that are available offer only marginal benefits overall, but are associated with clinically significant responses in as yet undefined subgroups. This chapter describes our current understanding of the genomics of pancreatic cancer and the potential impact of these findings on our approaches to treatment.

引用

页码：74 / 81

页数：8

共 56 条

[1]

Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2]

Deciphering Signatures of Mutational Processes Operative in Human Cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Campbell, Peter J. ;

Stratton, Michael R. .

CELL REPORTS, 2013, 3 (01) :246-259

[3]

ASCO, 2011, ACC PROGR CANC ASCOS

[4]

Novel cancer drivers: mining the kinome [J].

Biankin, Andrew V. ;

Grimmond, Sean M. .

GENOME MEDICINE, 2013, 5

[5]

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

[6]

Somatic variation and cancer: therapies lost in the mix [J].

Biankin, Andrew V. ;

Hudson, Thomas J. .

HUMAN GENETICS, 2011, 130 (01) :79-91

[7]

Towards systematic functional characterization of cancer genomes [J].

Boehm, Jesse S. ;

Hahn, William C. .

NATURE REVIEWS GENETICS, 2011, 12 (07) :487-498

[8]

Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients [J].

Byrski, T. ;

Huzarski, T. ;

Dent, R. ;

Gronwald, J. ;

Zuziak, D. ;

Cybulski, C. ;

Kladny, J. ;

Gorski, B. ;

Lubinski, J. ;

Narod, S. A. .

BREAST CANCER RESEARCH AND TREATMENT, 2009, 115 (02) :359-363

[9]

The patterns and dynamics of genomic instability in metastatic pancreatic cancer [J].

Campbell, Peter J. ;

Yachida, Shinichi ;

Mudie, Laura J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

Stebbings, Lucy A. ;

Morsberger, Laura A. ;

Latimer, Calli ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena A. ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Griffin, Constance A. ;

Burton, John ;

Swerdlow, Harold ;

Quail, Michael A. ;

Stratton, Michael R. ;

Iacobuzio-Donahue, Christine ;

Futreal, P. Andrew .

NATURE, 2010, 467 (7319) :1109-1113

[10]

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer [J].

Cheung, Hiu Wing ;

Cowley, Glenn S. ;

Weir, Barbara A. ;

Boehm, Jesse S. ;

Rusin, Scott ;

Scott, Justine A. ;

East, Alexandra ;

Ali, Levi D. ;

Lizotte, Patrick H. ;

Wong, Terence C. ;

Jiang, Guozhi ;

Hsiao, Jessica ;

Mermel, Craig H. ;

Getz, Gad ;

Barretina, Jordi ;

Gopal, Shuba ;

Tamayo, Pablo ;

Gould, Joshua ;

Tsherniak, Aviad ;

Stransky, Nicolas ;

Luo, Biao ;

Ren, Yin ;

Drapkin, Ronny ;

Bhatia, Sangeeta N. ;

Mesirov, Jill P. ;

Garraway, Levi A. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Root, David E. ;

Hahn, William C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (30) :12372-12377

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