Resveratrol inhibition of varicella-zoster virus replication in vitro

被引：93

作者：

Docherty, John J.

Sweet, Thomas J.

Bailey, Erin

Faith, Seth A.

Booth, Tristan

机构：

[1] Northeastern Ohio Univ Coll Med & Pharm, Rootstown, OH 44272 USA

[2] Royalmount Pharma, Montreal, PQ H4P 2T4, Canada

来源：

ANTIVIRAL RESEARCH | 2006年 / 72卷 / 03期

关键词：

resveratrol; varicella-zoster virus; cell infection;

D O I：

10.1016/j.antiviral.2006.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resveratrol was found to inhibit varicella-zoster virus (VZV) replication in a dose-dependent and reversible manner. This decrease in virus production in the presence of resveratrol was not caused by direct inactivation of VZV or inhibition of virus attachment to MRC-5 cells. The drug effectively limited VZV replication if added during the first 30 h of infection. Western blot analysis and real-time RT-PCR studies demonstrated that protein and mRNA levels of IE62, an essential immediate early viral protein, were reduced when compared to controls. These results;demonstrate that VZV replication is adversely affected by resveratrol which is negatively impacting IE62 synthesis. (c) 2006 Elsevier B.V All rights reserved.

引用

收藏

页码：171 / 177

页数：7

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