Structural biology of the chaperone-usher pathway of pilus biogenesis

被引：237

作者：

Waksman, Gabriel ^{[1
,2
]}

Hultgren, Scott J. ^{[3
]}

机构：

[1] UCL, Inst Struct & Mol Biol, London WC1E 7HX, England

[2] Birkbeck Coll, London WC1E 7HX, England

[3] Washington Univ, Ctr Womens Infect Dis Res, Sch Med, St Louis, MO 63110 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 11期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

UROPATHOGENIC ESCHERICHIA-COLI; BACTERIAL OUTER-MEMBRANE; URINARY-TRACT-INFECTIONS; SUBUNIT COMPLEX RECOGNITION; BLADDER EPITHELIAL-CELLS; ASSEMBLY PLATFORM FIMD; GRAM-NEGATIVE BACTERIA; DRIVES FIBER FORMATION; DONOR-STRAND EXCHANGE; RECEPTOR-BINDING;

D O I：

10.1038/nrmicro2220

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The chaperone-usher (CU) pathway of pilus biogenesis is the most widespread of the five pathways that assemble adhesive pili at the surface of Gram-negative bacteria. Recent progress in the study of the structural biology of the CU pathway has unravelled the molecular basis of chaperone function and elucidated the mechanisms of fibre assembly at the outer membrane, leading to a comprehensive description of each step in the biogenesis pathway. Other studies have provided the molecular basis of host recognition by CU pili. The knowledge that has been gathered about both the assembly of and host recognition by CU pili has been harnessed to design promising antibiotic compounds.

引用

页码：765 / 774

页数：10

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