Animal Models of Primary Biliary Cirrhosis

被引：34

作者：

Chuang, Ya-Hui ^{[2
]}

Ridgway, William M. ^{[3
]}

Ueno, Yoshiyuki ^{[4
]}

Gershwin, M. Eric ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

[2] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei, Taiwan

[3] Univ Pittsburgh, Sch Med, Div Rheumatol & Immunol, Pittsburgh, PA 15216 USA

[4] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Sendai, Miyagi 9808574, Japan

来源：

CLINICS IN LIVER DISEASE | 2008年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cld.2008.02.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary biliary cirrhosis (PBC) is well known as a disease that predominantly affects women and has been hitherto only described in humans. The absence of an animal model has significantly impaired research into both etiology and treatment. However, in the past 2 years, several spontaneous and two induced models of PBC were described. This article reviews the data on these animal models and places it in the perspective Of human PBC and generic autoimmunity.

引用

页码：333 / +

页数：16

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