The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

被引：184

作者：

Watts, C ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 07期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/ni1088

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The endosomes and lysosomes of antigen-presenting cells host the processing and assembly reactions that result in the display of peptides on major histocompatibility complex (MHC) class II molecules and lipid-linked products on CD1 molecules. This environment is potentially hostile for T cell epitope and MHC class II survival, and the influence of regulators of protease activity and specialized chaperones that assist MHC class II assembly is crucial. At present, evidence indicates that individual proteases make both constructive and destructive contributions to antigen processing for MHC class II presentation to CD4 T cells. Some features of CD1 antigen capture within the endocytic pathway are also discussed.

引用

收藏

页码：685 / 692

页数：8

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