Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase:: IoxP system

被引:8
作者
Wallace, DF
Tonks, ID
Zournazi, A
Kay, GF
Subramaniam, VN [1 ]
机构
[1] Queensland Inst Med Res, Membrane Transport Lab, Brisbane, Qld 4006, Australia
[2] Queensland Inst Med Res, Queensland Canc Fund Transgen Lab, Brisbane, Qld 4006, Australia
关键词
transferrin receptor 2; conditional knockout; hemochromatosis; iron homeostasis;
D O I
10.1002/gene.20023
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre-recombinase:loxP system used to create the mice allows both full deletion and tissue-specific deletion of TfR2. The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:38 / 41
页数:4
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