Towards a structural understanding of the anti-ulcer and anti-gastritis drug bismuth subsalicylate

被引：123

作者：

Andrews, Philip C. ^{[1
]}

Deacon, Glen B. ^{[1
]}

Forsyth, Craig M. ^{[1
]}

Junk, Peter C. ^{[1
]}

Kumar, Ish ^{[1
]}

Maguire, Melissa ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 34期

关键词：

bismuth oxide; bismuth; oxo ligands; salicylate ligands; solid-state structures;

D O I：

10.1002/anie.200600469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The action of Pepto-Bismol arising from the structure and hydrolysis of bismuth subsalicylate (BSS) is not yet understood. Two bismuth oxosalicylate clusters, [Bi38O44(HSal)26(Me 2CO)16(H2O)2] (1) and [Bi 9O7(HSal)13(Me2CO)5] (2), have been characterized which provide structural insight into the nature of BSS. A Bi9O7 cluster forms the core of 2 and is found at the heart of 1 (see picture; core Bi atoms: green, core O atoms: red). (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5638 / 5642

页数：5

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