Succinate dehydrogenase in Plasmodium falciparum mitochondria:: molecular characterization of the SDHA and SDHB genes for the catalytic subunits, the flavoprotein (Fp) and iron-sulfur (Ip) subunits

被引：35

作者：

Takeo, S

Kokaze, A

Ng, CS

Mizuchi, D

Watanabe, J

Tanabe, K

Kojima, S

Kita, K

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Biomed Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Parasitol, Minato Ku, Tokyo 1080071, Japan

[3] Osaka Inst Technol, Biol Lab, Asahi Ku, Osaka 5358585, Japan

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2000年 / 107卷 / 02期

关键词：

Plasmodium falciparum; mitochondria; succinate dehydrogenase; SDHA; SDHB;

D O I：

10.1016/S0166-6851(00)00185-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA, as well as almost all the conserved amino acids indispensable for substrate binding and the catalytic reaction were found in these peptides, indicating the functional importance of this enzyme in the parasite. Interestingly, a P. falciparum-specific insertion and a unicellular organism-specific deletion were found in the amino acid sequence of Fp. This is the first report of the primary structure of the protozoan succinate dehydrogenase. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：191 / 205

页数：15

共 60 条

[31] SEQUENCE COMPARISON BETWEEN THE FLAVOPROTEIN SUBUNIT OF THE FUMARATE REDUCTASE (COMPLEX-II) OF THE ANAEROBIC PARASITIC NEMATODE, ASCARIS-SUUM AND THE SUCCINATE-DEHYDROGENASE OF THE AEROBIC, FREE-LIVING NEMATODE, CAENORHABDITIS-ELEGANS [J].