Noncognate function of B cells in transplantation

被引：5

作者：

Balin, Samuel J.

Platt, Jeffrey L. ^{[1
]}

Cascalho, Marilia

机构：

[1] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

来源：

TRANSPLANT INTERNATIONAL | 2009年 / 22卷 / 06期

关键词：

antibodies; B cell; T cell; transplantation; CARDIAC ALLOGRAFT-REJECTION; ANTIGEN-PRESENTING CELLS; T-CELLS; IN-VIVO; MONOCLONAL-ANTIBODY; ACCOMMODATION; LYMPHOCYTES; MEMORY; XENOTRANSPLANTATION; RITUXIMAB;

D O I：

10.1111/j.1432-2277.2008.00816.x

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

How B cells affect the outcome of transplants is a question of enduring interest. Initial efforts to answer that question suggested, wrongly, that B cells have no impact on transplantation. Now, however, B cells are known to influence not only the outcome of vascularized grafts through the production of anti-donor antibodies but also the competence of cellular immunity through a number of physiologic functions. In this study, we explain why the importance of B cells was overlooked in the past and consider the range of noncognate functions of B cells that may determine the outcome of transplants.

引用

收藏

页码：593 / 598

页数：6

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