Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood

被引：152

作者：

Gregori, L

McCombie, N

Palmer, D

Birch, P

Sowemimo-Coker, S

Giulivi, A

Rohwer, RG

机构：

[1] Univ Maryland, Vet Affairs Med Ctr, Vet Affairs Maryland Hlth Care Syst, Baltimore, MD 21201 USA

[2] Hlth Canada, Ctr Infect Dis Prevent & Control, Ottawa, ON K1A 0L2, Canada

[3] Canadian Blood Serv, Ottawa, ON, Canada

[4] Pall Corp, Port Washington, NY USA

来源：

LANCET | 2004年 / 364卷 / 9433期

关键词：

D O I：

10.1016/S0140-6736(04)16812-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 1999, the UK implemented universal leucoreduction as a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blood or red blood cells. We aimed to assess how effectively leucoreduction reduced infectivity of transmissible spongiform encephalopathies (TSEs) in blood. 450 mL of whole blood collected and pooled from scrapie-infected hamsters was leucoreduced with a commercial filter. Blood cell concentrations were quantified, and infectivity titres measured. Blood cell recovery and white blood cell removal complied with American Association of Blood Banks standards. Leucofiltration removed 42% (SD 12) of the total TSE infectivity in endogenously infected blood. Leucoreduction is necessary for the removal of white-cell-associated TSE infectivity from blood; however, it is not, by itself, sufficient to remove all blood-borne TSE infectivity.

引用

页码：529 / 531

页数：3

共 7 条

[1] Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans [J].