Fractionation and anti-tumor activity of the mycelia of liquid-cultured Phellinas linteus

被引：58

作者：

Nakamura, T

Matsugo, S

Uzuka, Y

Matsuo, S

Kawagishi, H

机构：

[1] IBI Corp, Appl Fungi Inst, Yamanashi 4070263, Japan

[2] Yamanashi Univ, Interdisciplinary Grad Sch Med & Engn, Div Appl Biol Sci, Yamanashi 4008511, Japan

[3] Kitasato Univ, Dept Pharmacol, Sagamihara, Kanagawa 2288555, Japan

[4] Shizuoka Univ, Fac Agr, Shizuoka 4228529, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 04期

关键词：

protein-alpha-1,3-glucan complex; anti-tumor activity; NMR; mycelia; Phellinus linteus;

D O I：

10.1271/bbb.68.868

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0. This protein-glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its C-13- and H-1-NMR data showed that the main glucan part of the complex was simple alpha-1,3-glucan chains.

引用

页码：868 / 872

页数：5

共 17 条

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COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].