Enhanced epileptogenesis in S100B knockout mice

被引:44
作者
Dyck, RH
Bogoch, II
Marks, A
Melvin, NR
Teskey, GC
机构
[1] Univ Calgary, Dept Psychol, Behav Neurosci Res Grp, Calgary, AB T2N 1N4, Canada
[2] Univ Calgary, Dept Neurosci, Calgary, AB T2N 1N4, Canada
[3] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON, Canada
来源
MOLECULAR BRAIN RESEARCH | 2002年 / 106卷 / 1-2期
基金
加拿大自然科学与工程研究理事会;
关键词
astrocyte; seizure; epilepsy; kindling; amygdala; S100B; glial fibrillary acidic protein;
D O I
10.1016/S0169-328X(02)00406-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
S100B is a small calcium- and zinc-binding protein expressed by astrocytes in the central nervous system. Here, we examined the role of S100B in epileptogenesis using an amygdala kindling paradigm comparing S100B knockout mice with their wild-type counterparts. Astrocyte activation following kindling, assessed by glial fibrillary acidic protein expression in the hippocampus and amygdala, was similar in wild-type and knockout mice. In addition, wild-type and knockout mice did not have substantially different afterdischarge thresholds. However, knockout mice kindled more rapidly and exhibited more severe seizures. These results implicate normal levels of S100B in the attenuation of epileptogenesis. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:22 / 29
页数:8
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