Meiotic recombination in mammals: localization and regulation

被引：485

作者：

Baudat, Frederic ^{[1
]}

Imai, Yukiko ^{[1
]}

de Massy, Bernard ^{[1
]}

机构：

[1] CNRS, Inst Human Genet, Unite Propre Rech 1142, F-34396 Montpellier, France

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 11期

关键词：

DOUBLE-STRAND BREAKS; DNA MISMATCH REPAIR; SYNAPTONEMAL COMPLEX; HOMOLOGOUS RECOMBINATION; CROSSING-OVER; HOT-SPOTS; HISTONE METHYLTRANSFERASE; PSEUDOAUTOSOMAL REGION; GENETIC-RECOMBINATION; CHROMOSOME SYNAPSIS;

D O I：

10.1038/nrg3573

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the exchange of genetic material between homologous chromosomes. These exchanges increase genome diversity and are essential for proper chromosome segregation at the first meiotic division. Recent findings have highlighted an unexpected molecular control of the distribution of meiotic DSBs in mammals by a rapidly evolving gene, PR domain-containing 9 (PRDM9), and genome-wide analyses have facilitated the characterization of meiotic DSB sites at unprecedented resolution. In addition, the identification of new players in DSB repair processes has allowed the delineation of recombination pathways that have two major outcomes, crossovers and non-crossovers, which have distinct mechanistic roles and consequences for genome evolution.

引用

页码：794 / 806

页数：13

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