Treatment Policy rather than Patient Characteristics Determines Convection Volume in Online Post-Dilution Hemodiafiltration

被引：30

作者：

Chapdelaine, Isabelle ^{[1
]}

Mostovaya, Ira M. ^{[2
]}

Blankestijn, Peter J. ^{[2
]}

Bots, Michiel L. ^{[3
]}

van den Dorpel, Marinus A. ^{[4
]}

Levesque, Renee ^{[5
]}

Nube, Menso J. ^{[1
,6
]}

ter Wee, Piet M. ^{[1
,6
]}

Grooteman, Muriel P. C. ^{[1
,6
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Nephrol, Amsterdam, Netherlands

[2] Univ Med Ctr Utrecht, Dept Nephrol, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[4] Maasstad Hosp, Dept Internal Med, Rotterdam, Netherlands

[5] St Luc Hosp, Ctr Hosp Univ Montreal, Dept Nephrol, Montreal, PQ, Canada

[6] Vrije Univ Amsterdam Med Ctr, Inst Cardiovasc Res VU Med Ctr ICaR VU, Amsterdam, Netherlands

来源：

BLOOD PURIFICATION | 2014年 / 37卷 / 03期

关键词：

Dialysis; Hemodiafiltration; Convection volume; Vascular access; Filtration fraction; Dialyzer; PATIENTS RECEIVING HEMODIAFILTRATION; ALL-CAUSE MORTALITY; INTRADIALYTIC HYPOTENSION; CHRONIC-HEMODIALYSIS; RISK; EFFICIENCY; SURVIVAL; FLUX;

D O I：

10.1159/000362108

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background/Aims: Sub-analyses of three large trials showed that hemodiafiltration (HDF) patients who achieved the highest convection volumes had the lowest mortality risk. The aims of this study were (1) to identify determinants of convection volume and (2) to assess whether differences exist between patients achieving high and low volumes. Methods: HDF patients from the CONvective TRAnsport STudy (CONTRAST) with a complete dataset at 6 months (314 out of a total of 358) were included in this post hoc analysis. Determinants of convection volume were identified by regression analysis. Results: Treatment time, blood flow rate, dialysis vintage, serum albumin and hematocrit were independently related. Neither vascular access nor dialyzer characteristics showed any relation with convection volume. Except for some variation in body size, patient characteristics did not differ across tertiles of convection volume. Conclusion: Treatment time and blood flow rate are major determinants of convection volume. Hence, its magnitude depends on center policy rather than individualized patient prescription. (C) 2014 S. Karger AG, Basel

引用

页码：229 / 237

页数：9

共 30 条

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Clinical application of Ultracontrol®: infusion volume and use with different dialyzers [J].