CTGF and Apoptosis in Mouse Osteocytes Induced by Tooth Movement

被引：57

作者：

Sakai, Y. ^{[1
]}

Balam, T. A. ^{[2
]}

Kuroda, S. ^{[2
]}

Tamamura, N. ^{[2
]}

Fukunaga, T. ^{[3
]}

Takigawa, M. ^{[4
]}

Takano-Yamamoto, T. ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Dent, Div Orthodont & Dentofacial Orthoped, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Orthodont & Dentofacial Orthoped, Okayama 7008530, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Orthodont, Kagoshima 890, Japan

[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Biochem & Mol Dent, Okayama 7008530, Japan

来源：

JOURNAL OF DENTAL RESEARCH | 2009年 / 88卷 / 04期

关键词：

connective tissue growth factor (CTGF); mechanical stimulation; osteocyte; apoptosis; in situ hybridization; TISSUE GROWTH-FACTOR; CHONDROCYTE-SPECIFIC GENE; VASCULAR ENDOTHELIAL-CELLS; IN-VIVO; MECHANICAL-STRESS; ALVEOLAR BONE; EXPRESSION; PRODUCT; RAT; DIFFERENTIATION;

D O I：

10.1177/0022034509334649

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

It is known that experimental tooth movement stimulates the gene expression of connective tissue growth factor (CTGF) and induces apoptosis in osteocytes in rats. We hypothesized that there is a relationship between CTGF expression and the induction of apoptosis in osteocytes, to play a significant role in triggering bone remodeling during experimental tooth movement. In this study, CTGF mRNA expression was detected at 2 hours in osteocytes on the pressure side, followed by apoptosis at 6 hours after tooth movement in mice. The number of empty lacunae significantly increased on day 1 after mechanical stimulation. Thereafter, the number of osteoclasts significantly increased on the pressure side of the alveolar bone on day 3. Tooth movement increased rapidly on day 10. These findings suggest that CTGF expression, followed by apoptosis in osteocytes in response to mechanical stimulation, might play a significant role in triggering bone remodeling during tooth movement.

引用

页码：345 / 350

页数：6

共 25 条

[1]

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction [J].