Simultaneous atomic force microscope and quartz crystal microbalance measurements: Investigation of human plasma fibrinogen adsorption

被引：29

作者：

Choi, KH ^{[1
]}

Friedt, JM ^{[1
]}

Frederix, F ^{[1
]}

Campitelli, A ^{[1
]}

Borghs, G ^{[1
]}

机构：

[1] Interuniv Microelect Ctr, MCP ACSS, B-3001 Louvain, Belgium

来源：

APPLIED PHYSICS LETTERS | 2002年 / 81卷 / 07期

关键词：

D O I：

10.1063/1.1500777

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We have combined the tapping-mode atomic force microscope (AFM) and quartz crystal microbalance (QCM) for simultaneous investigation of human plasma fibrinogen adsorption on a metallic surface using these two instruments. The AFM images show the surface changes with molecular resolution while the corresponding resonance frequency shift of the QCM provides quantitative adsorbed mass estimates over the whole sensing area. The combination of AFM with QCM allowing the simultaneous measurements with two techniques working at very different scales and probing different properties of the adsorbed layer provides quantitative and qualitative information that can distinguish different protein adsorption mechanisms. (C) 2002 American Institute of Physics.

引用

页码：1335 / 1337

页数：3