Temporal sequence of hemispheric network activation during semantic processing: A functional network connectivity analysis

被引:25
作者
Assaf, Michal [1 ,2 ]
Jagannathan, Kanchana [1 ]
Calhoun, Vince [1 ,2 ,3 ,4 ]
Kraut, Michael [5 ]
Hart, John, Jr. [6 ]
Pearlson, Godfrey [1 ,2 ]
机构
[1] Hartford Hosp, Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT 06106 USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[3] Mind Res Network, Albuquerque, NM USA
[4] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
[5] Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21205 USA
[6] Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75235 USA
关键词
Semantic memory; Independent component analysis; ICA; Functional network connectivity; FNC; Right hemisphere; INDEPENDENT COMPONENT ANALYSIS; RETRIEVAL TEST SORT; TIME-COURSE; BLIND SEPARATION; OBJECT-RECALL; DEFAULT-MODE; FMRI DATA; MRI DATA; BRAIN; MEMORY;
D O I
10.1016/j.bandc.2009.02.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To explore the temporal sequence of, and the relationship between, the left and right hemispheres (LH and RH) during semantic memory (SM) processing we identified the neural networks involved in the performance of functional MRI semantic object retrieval task (SORT) using group independent component analysis (ICA) in 47 healthy individuals. SORT requires participants to determine whether word pairs describing object features combine to retrieve an object. Functional network connectivity (FNC) was used to assess the correlations between components' time courses. Results showed that semantic left and right hemisphere networks comprise two independent ICA components. The components' time courses were highly correlated and RH activation preceded that of the LH. Moreover, this correlation was significantly stronger in better vs. poorer performers of the SORT. These results indicate an early activation of the RH that is closely followed by activation of the LH, to facilitate performance during word retrieval from SM. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:238 / 246
页数:9
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