A chip-based capillary electrophoresis-contactless conductivity microsystem for fast measurements of low-explosive ionic components

被引:81
作者
Wang, J [1 ]
Pumera, M
Collins, G
Opekar, F
Jelinek, I
机构
[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA
[2] USN, Res Lab, Div Chem, Washington, DC 20375 USA
[3] Charles Univ, Dept Analyt Chem, Prague 12043 2, Czech Republic
关键词
D O I
10.1039/b201700h
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A miniaturized analytical system for separating and detecting inorganic explosive residues, based on the coupling of a micromachined capillary electrophoresis (CE) chip with a contactless conductivity detector is described. The low electroosmotic flow (EOF) of the poly(methylmethacrylate) (PMMA) chip material facilitates the rapid switching between analyses of cations and anions using the same microchannel and run buffer (and without an EOF modifier), and hence offers rapid ( < 1 min) measurement of seven explosive-related cations and anions. Experimental parameters relevant to the separation and detection processes have been optimized. Addition of a 18-crown-6 ether modifier has been used for separating the peaks of co-migrating potassium and ammonium ions. The ionic-explosive microchip system combines the distinct advantages of contactless conductivity detection with the attractive features of plastic CE microchips. The new microsystem offers great promise for monitoring explosive-related ions at the sample source, with significant advantages of speed/warning, efficiency; cost, or sample size.
引用
收藏
页码:719 / 723
页数:5
相关论文
共 24 条
[1]  
[Anonymous], 1964, Chemistry and Technology of Explosives
[2]   Plastic advances microfluidic devices. [J].
Boone, T ;
Fan, ZH ;
Hooper, H ;
Ricco, A ;
Tan, HD ;
Williams, S .
ANALYTICAL CHEMISTRY, 2002, 74 (03) :78A-86A
[3]  
da Silva JAF, 1998, ANAL CHEM, V70, P4339
[4]   Novel electrolyte for the analysis of cations in low explosive residue by capillary electrophoresis [J].
Doyle, JM ;
McCord, BR .
JOURNAL OF CHROMATOGRAPHY B, 1998, 714 (01) :105-111
[5]   A new PMMA-microchip device for isotachophoresis with integrated conductivity detector [J].
Grass, B ;
Neyer, A ;
Jöhnck, M ;
Siepe, D ;
Eisenbeiss, F ;
Weber, G ;
Hergenröder, R .
SENSORS AND ACTUATORS B-CHEMICAL, 2001, 72 (03) :249-258
[6]  
Guijt RM, 2001, ELECTROPHORESIS, V22, P235, DOI 10.1002/1522-2683(200101)22:2<235::AID-ELPS235>3.0.CO
[7]  
2-O
[8]   Electrochemical detectors prepared by electroless deposition for microfabricated electrophoresis chips [J].
Hilmi, A ;
Luong, JHT .
ANALYTICAL CHEMISTRY, 2000, 72 (19) :4677-4682
[9]   Application of capillary electrophoresis for the determination of inorganic ions in trace explosives and explosive residues [J].
Kishi, T ;
Nakamura, J ;
Arai, H .
ELECTROPHORESIS, 1998, 19 (01) :3-5
[10]   Capillary electrophoresis and contactless conductivity detection of ions in narrow inner diameter capillaries [J].
Mayrhofer, K ;
Zemann, AJ ;
Schnell, E ;
Bonn, GK .
ANALYTICAL CHEMISTRY, 1999, 71 (17) :3828-3833