Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant

被引：44

作者：

Malley, R

Morse, SC

Leite, LCC

Areas, APM

Ho, PL

Kubrusly, FS

Almeida, IC

Anderson, P

机构：

[1] Childrens Hosp, Div Infect Dis, Dept Med, Boston, MA 02115 USA

[2] Univ Sao Paulo, Inst Butantan, BR-05508 Sao Paulo, Brazil

[3] Univ Sao Paulo, Dept Parasitol, Inst Biomed Sci, BR-05508 Sao Paulo, Brazil

[4] Univ Sao Paulo, Inst Chem, BR-05508 Sao Paulo, Brazil

[5] Univ Rochester, Dept Pediat, Div Infect Dis & Immunol, Rochester, NY USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 07期

关键词：

D O I：

10.1128/IAI.72.7.4290-4292.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective.

引用

收藏

页码：4290 / 4292

页数：3

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