Polyester-based carborane-containing dendrons

被引：21

作者：

Galie, Kristin M. ^{[1
]}

Mollard, Alexis ^{[1
]}

Zharov, Ilya ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

INORGANIC CHEMISTRY | 2006年 / 45卷 / 19期

关键词：

NEUTRON-CAPTURE THERAPY; MOLECULAR-WEIGHT; O-CARBORANE; DENDRIMERS; CHEMISTRY; DERIVATIVES; DELIVERY; DECABORANE; POLYMERS; LIGANDS;

D O I：

10.1021/ic060866r

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New carborane-containing dendrons based on a 2,2-bis(hydroxymethyl) propanoic acid scaffold have been prepared for applications in boron neutron capture therapy. A generation-2 carborane-containing dendron carrying 40 boron atoms was the highest generation synthetically available due to the steric crowding. The structure of this dendron has been simulated by molecular dynamics. A 10-carbon linker carrying a carboxylic group has been installed at the focal point of the dendron to distance the attachment point from the sterically hindered core.

引用

页码：7815 / 7820

页数：6

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