Intranasal absorption of oxymorphone

被引：14

作者：

Hussain, MA ^{[1
]}

Aungst, BJ ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,PHARMACEUT R&D,WILMINGTON,DE 19880

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1997年 / 86卷 / 08期

关键词：

D O I：

10.1021/js960513x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The nasal bioavailability of oxymorphone HCl was determined. Rats were surgically prepared to isolate the nasal cavity, into which a solution of oxymorphone was administered. A reference group of rats was administered oxymorphone HCl intravenously. Plasma oxymorphone concentrations were determined by HPLC. Nasal absorption was rapid, nasal bioavailability was 43%, and the iv and nasal elimination profiles were similar. Oxymorphone HCl appears to have the solubility, potency, and absorption properties required for efficient nasal delivery, which is an alternative to injections.

引用

页码：975 / 976

页数：2

共 13 条

[1] TRANSNASAL BUTORPHANOL - A NEW METHOD FOR PAIN RELIEF IN POSTCESAREAN SECTION PAIN [J].

ABBOUD, TK ;

ZHU, J ;

GANGOLLY, J ;

LONGHITANO, M ;

SWART, F ;

MAKAR, A ;

CHU, G ;

COOL, M ;

MANTILLA, M ;

KURTZ, N ;

REICH, L .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1991, 35 (01) :14-18

[2] COMPARISONS OF ANALGESIC EFFECTS OF ORAL AND INTRAMUSCULAR OXYMORPHONE AND OF INTRAMUSCULAR OXYMORPHONE AND MORPHINE IN PATIENTS WITH CANCER [J].

BEAVER, WT ;

WALLENSTEIN, SL ;

HOUDE, RW ;

ROGERS, A .

JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 17 (04) :186-198

[3] TRANSNASAL BUTORPHANOL - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN ACUTE PAIN MANAGEMENT [J].

GILLIS, JC ;

BENFIELD, P ;

GOA, KL .

DRUGS, 1995, 50 (01) :157-175

[4] NASAL ABSORPTION OF NALOXONE AND BUPRENORPHINE IN RATS [J].

HUSSAIN, A ;

KIMURA, R ;

HUANG, CH ;

KASHIHARA, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1984, 21 (02) :233-237

[5] NASAL ABSORPTION OF PROPRANOLOL IN RATS [J].

HUSSAIN, AA ;

HIRAI, S ;

BAWARSHI, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (09) :1196-1196

[6] BUCCAL AND ORAL BIOAVAILABILITY OF NALOXONE AND NALTREXONE IN RATS [J].

HUSSAIN, MA ;

AUNGST, BJ ;

KEARNEY, A ;

SHEFTER, E .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (2-3) :127-130

[7] BUCCAL AND ORAL BIOAVAILABILITY OF NALBUPHINE IN RATS [J].

HUSSAIN, MA ;

AUNGST, BJ ;

SHEFTER, E .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (02) :218-219

[8] IMPROVED BUCCAL DELIVERY OF OPIOID ANALGESICS AND ANTAGONISTS WITH BITTERLESS PRODRUGS [J].

HUSSAIN, MA ;

AUNGST, BJ ;

KOVAL, CA ;

SHEFTER, E .

PHARMACEUTICAL RESEARCH, 1988, 5 (09) :615-618

[9] INTRANASAL ABSORPTION OF PHYSOSTIGMINE AND ARECOLINE [J].

HUSSAIN, MA ;

MOLLICA, JA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1991, 80 (08) :750-751

[10] INTRANASAL ABSORPTION OF A KAPPA-AGONIST ANALGESIC [J].

HUSSAIN, MA ;

SCHMIDT, WK ;

BUEHLER, JD .

PHARMACEUTICAL RESEARCH, 1993, 10 (07) :1083-1086

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