The fertile field of Drosophila JAK/STAT signalling

被引：133

作者：

Hombría, JCG ^{[1
]}

Brown, S ^{[1
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 16期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-9822(02)01057-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The JAK/STAT pathway plays important roles in vertebrate and invertebrate development. The recent cloning and characterisation of the receptor in Drosophila shows that the pathway is conserved across phyla. In this review we describe current knowledge of the pathway and use genome data to discuss what elements are present in Drosophila. We also summarise recent work describing the involvement of the JAK/STAT pathway in oogenesis and spermatogenesis. Interestingly, the JAK/STAT pathway maintains the niche required for germline stem cell maintenance in the testis, providing the first molecular characterisation of a stem cell niche. Drosophila's streamlined pathway offers a simple model to find new elements and analyse the function of existing ones.

引用

页码：R569 / R575

页数：7

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